This tool is for research exploration only. It is not a medical device and does not provide medical advice. Drug candidates, evidence scores, and AI-generated content are not clinical recommendations. Always consult your medical team before making any treatment decisions.

Drug Candidates

13 candidates mapped to SDH-deficient disease pathways

All (27)established (4)clinical trial (4)preclinical (13)theoretical (6)
Olaparib

Lynparza

preclinical

PARP inhibitor (PARP1/2)

Sdh Driven HrdOxidative Stress Ros
Evidence Score
58
FDA Approved
Everolimus

Afinitor

preclinical

mTOR inhibitor (rapalog)

Mtor Pi3k Akt
Evidence Score
55
FDA Approved
Azacitidine

Vidaza

preclinical

DNA methyltransferase inhibitor (hypomethylating agent)

Epigenetic Dysregulation
Evidence Score
52
FDA Approved
Decitabine

Dacogen

preclinical

DNA methyltransferase inhibitor (hypomethylating agent)

Epigenetic Dysregulation
Evidence Score
50
FDA Approved
Daporinad (FK866)

APO866

preclinical

NAMPT inhibitor (NAD⁺ biosynthesis inhibitor)

Nad MetabolismOxidative Stress Ros
Evidence Score
48
Hydroxychloroquine

Plaquenil

preclinical

Autophagy inhibitor (lysosomal alkalinizer)

Autophagy Survival
Evidence Score
42
FDA Approved
Metformin

Glucophage

preclinical

Biguanide / Complex I inhibitor / AMPK activator

Mtor Pi3k AktOxidative Stress Ros
Evidence Score
40
FDA Approved
Ascorbic Acid (High-dose IV)
preclinical

TET enzyme cofactor / α-KG-dependent dioxygenase activator

Epigenetic DysregulationOxidative Stress Ros
Evidence Score
38
DENSPM (N1,N11-Diethylnorspermine)
preclinical

Polyamine analogue / SSAT inducer

Polyamine MetabolismOxidative Stress Ros
Evidence Score
38
Dichloroacetate (DCA)
preclinical

Pyruvate dehydrogenase kinase inhibitor

Hif PseudohypoxiaOxidative Stress Ros
Evidence Score
35
Ceralasertib

AZD6738

preclinical

ATR kinase inhibitor

Atrx Alt Replication Stress
Evidence Score
33
AZD3965
preclinical

MCT1 inhibitor (monocarboxylate transporter 1 inhibitor, SLC16A1)

Succinate Immune Evasion
Evidence Score
30
Pevonedistat

TAK-924

preclinical

NAE inhibitor (neddylation inhibitor, NEDD8-activating enzyme inhibitor)

Neddylation
Evidence Score
30