Drug Candidates

4 candidates mapped to SDH-deficient disease pathways

All (15)established (4)clinical trial (2)preclinical (6)theoretical (3)
Belzutifan

Welireg

established

HIF-2α inhibitor

Hif Pseudohypoxia
Evidence Score
82
FDA Approved
Sunitinib

Sutent

established

Multi-kinase inhibitor (VEGFR/PDGFR/KIT)

Vegf SignalingMtor Pi3k Akt
Evidence Score
75
FDA Approved
Bevacizumab

Avastin

established

Anti-VEGF monoclonal antibody

Vegf Signaling
Evidence Score
65
FDA Approved
Regorafenib

Stivarga

established

Multi-kinase inhibitor (VEGFR/KIT/PDGFR/FGFR/RAF)

Vegf SignalingMtor Pi3k Akt
Evidence Score
58
FDA Approved